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The Tutwiler laboratory is focused on studying the structure-function relationship of blood clot formation, with a particular focus on the mechanics and enzymatic function. Immune cells and inflammation play a unique role in the activation and regulation of blood clotting and warrant further examination. We are particularly interested in examining the role of inflammation due to its pathophysiolgical relevance to traumatic injury, cancer, spinal cord injury etc. We aim to explore the mechanisms of inflammation can exasperate the dysregulation of coagulation. The exact project specifications will be tailored to the individual student based on their major and interests but will span cell culture/imaging, analysis of patient samples (including potential for ML applications), and/or mechanics.
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