"The organization of the cell's genome in three dimensions is fundamental to different cellular functions. The nucleus is divided into distinct chromosomal territories and each chromsome is segregated into active or repressed regions. While the utility of organizing the chormsome remains under investigation, it is known that multiple mechanisms orchestrate DNA organization. Crucially, Topologically Associating Domains (TADs) serve as key structural units, forming DNA loops that physically segregate (...)
Life Sciences Alliance SURF
SAS - DLS - Cell Biology and Neuroscience
Cell & Molecular Biology, Genomics , Life Sciences
"Here, we aim to develop surrogate deep learning models to replace finite element (FE) modeling and optimization for characterizing the mechanical response of soft tissues such as brain white matter. The forward problem of predicting the evolution of stress for a given tissue geometry—typically performed using FE modeling—is replaced by a recurrent neural network (RNN) that learns the structure–property relationship between tissue microstructure, material properties and stress-strain behavior. The (...)
Life Sciences Alliance SURF
Engn - Mechanical & Aerospace Engineering
Artificial Intelligence, Data Science, Life Sciences
This research project introduces a Unified Computational Framework to integrate cell morphology with single-cell transcriptomics. The proposal employs deep learning to perform morphometrics, extracting fine-grained, structural features (shape, size, morphology) of individual cochlear cells from immunofluorescent images. This structural information is then unified with corresponding single-cell genomics data, to reveal the molecular identity of the same cell types through their gene expression profiles. (...)
Life Sciences Alliance SURF
SAS - DLS - Cell Biology and Neuroscience
Artificial Intelligence, Data Science, Life Sciences
"Age-related decline in auditory processing and memory for speech significantly impacts social well-being, contributing to social avoidance, isolation, depression, and anxiety. Despite these comorbidities, animal models for studying this decline have been limited due to the complex nature of human vocal processing. Songbirds, which learn vocalizations through social interaction (similarly to humans), offer a promising alternative model system.
This study introduces an innovative approach that (...)
Life Sciences Alliance SURF
SAS - Center for Cognitive Sciences
Cognitive Science, Life Sciences
The current project aims to improve spectrophotometric testing—a branch of chemical physics—in environmental applications by applying AI/ML techniques. Spectrophotometry is a powerful analytical technique based on the principle that every chemical absorbs light at specific wavelengths, enabling identification and quantification of hundreds of substances in chemistry, biology, and medicine (think color-change-based measurements in blood glucose monitors, chlorine test strips in swimming pools, or (...)
RAD Collaboration
SEBS - Environmental Science
Computer Science and Engineering, Information Technology, (...)
