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The Lonergan Lab is broadly interested in discovering how opportunistic bacterial pathogens sense and respond to nitric oxide. Nitric oxide is produced as part of the host immune response against invading pathogens. However, certain organisms can overcome host-mediated nitric oxide production and cause disease, which suggests we do not fully understand how nitric oxide limits pathogen survival. Therefore, this summer research experience will utilize molecular biology and genetic techniques to interrogate the response of the opportunistic pathogen Pseudomonas aeruginosa to nitric oxide. Students will learn fundamentals in molecular microbiology, genetics, and biochemistry and work alongside members of the laboratory to uncover new mechanisms of bacterial nitric oxide sensing and detoxification.
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