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Total bilirubin, a routinely measured laboratory marker that traditionally is known as a marker of liver dysfunction, has emerging protective associations with oxidative stress, metabolic health, and cardiometabolic risk. However, the relationship between short-term changes in total bilirubin levels and cardiometabolic health parameters remains incompletely characterized in real-world clinical populations.
The purpose of this study is to evaluate the association between changes in body weight and waist circumference and corresponding changes in total bilirubin over a 6-month period using cohort data from NIH's All of Us dataset as well as local retrospective electronic health record (EHR) data. Specifically, this study will assess whether weight loss, weight gain, or weight stability are associated with directional or magnitude changes in total bilirubin levels in adult patients taking GLP-1 weight loss medications, and whether changes in bilirubin mediate changes in cardiometabolic health parameters including blood glucose, lipids, and blood pressure.
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